BDBM50045598 CHEMBL3314311::US9540323, 220::US9540323, example 220

SMILES CC1(C)CN(c2c1c(c(F)cc2O)-c1ccc(Cl)cc1)c1ccccc1NC(=O)Nc1ccc(OC(F)(F)F)cc1

InChI Key InChIKey=GKKHXSFPYJSHCX-UHFFFAOYSA-N

Data  2 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50045598   

TargetP2Y purinoceptor 1(Human)
Bristol-Myers Squibb Research

Curated by ChEMBL
LigandPNGBDBM50045598(US9540323, 220 | CHEMBL3314311 | US9540323, exampl...)
Affinity DataIC50: 1.10nMAssay Description:Antagonist activity at P2Y1 receptor in washed human platelets assessed as 1 uM 2-methylthio-ADP-induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2016
Entry Details Article
PubMed
TargetP2Y purinoceptor 1(Human)
Bristol-Myers Squibb Research

Curated by ChEMBL
LigandPNGBDBM50045598(US9540323, 220 | CHEMBL3314311 | US9540323, exampl...)
Affinity DataIC50: 240nMAssay Description:Antagonist activity at P2Y1 receptor in platelet-enriched human plasma assessed as 10 uM ADP-induced platelet aggregation preincubated for 1 min foll...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2016
Entry Details Article
PubMed
TargetP2Y purinoceptor 1(Human)
Bristol-Myers Squibb Research

Curated by ChEMBL
LigandPNGBDBM50045598(US9540323, 220 | CHEMBL3314311 | US9540323, exampl...)
Affinity DataIC50: 1.10nMAssay Description:Antagonist activity at human P2Y1 by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetPhospholipase A2, membrane associated(Human)
University of Nottingham

Curated by ChEMBL
LigandPNGBDBM50045598(US9540323, 220 | CHEMBL3314311 | US9540323, exampl...)
Affinity DataIC50: 240nMAssay Description:Antagonist activity at human pA2 by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetP2Y purinoceptor 1(Human)
Bristol-Myers Squibb Research

Curated by ChEMBL
LigandPNGBDBM50045598(US9540323, 220 | CHEMBL3314311 | US9540323, exampl...)
Affinity DataKi:  14nM ΔG°:  -10.7kcal/molepH: 7.4 T: 2°CAssay Description:A SPA membrane binding assay was used to identify inhibitors of [33P] 2MeS-ADP binding to cloned human P2Y1 receptors (The P2Y1 receptor membranes we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2018
Entry Details
Go to US Patent

TargetP2Y purinoceptor 1(Human)
Bristol-Myers Squibb Research

Curated by ChEMBL
LigandPNGBDBM50045598(US9540323, 220 | CHEMBL3314311 | US9540323, exampl...)
Affinity DataKi:  14nM ΔG°:  -10.7kcal/molepH: 7.4 T: 2°CAssay Description:A SPA membrane binding assay was used to identify inhibitors of [33P] 2MeS-ADP binding to cloned human P2Y1 receptors (The P2Y1 receptor membranes we...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2018
Entry Details
Go to US Patent