BDBM50044667 CHEMBL3353362::US10358436, Example A58::US9907800, Example A58

SMILES O=C1Nc2ccccc2[C@]11C[C@H]1c1ccc2c(\C=C\c3ccc(CN4CCCCC4)cc3)n[nH]c2c1

InChI Key InChIKey=QRDCBCOPUDYBCB-UHFFFAOYSA-N

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50044667   

TargetAurora kinase B(Human)
Entremed

Curated by ChEMBL
LigandPNGBDBM50044667(CHEMBL3353362 | US9907800, Example A58 | US1035843...)
Affinity DataIC50: 14nMAssay Description:Inhibition of AURKB (unknown origin) by FRET-based homogeneous assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2016
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Entremed

Curated by ChEMBL
LigandPNGBDBM50044667(CHEMBL3353362 | US9907800, Example A58 | US1035843...)
Affinity DataIC50: 15nMAssay Description:Inhibition of FLT3 (unknown origin) by FRET-based homogeneous assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2016
Entry Details Article
PubMed
LigandPNGBDBM50044667(CHEMBL3353362 | US9907800, Example A58 | US1035843...)
Affinity DataIC50: 12nMAssay Description:Inhibition of KDR (unknown origin) by FRET-based homogeneous assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK4(Human)
Entremed

Curated by ChEMBL
LigandPNGBDBM50044667(CHEMBL3353362 | US9907800, Example A58 | US1035843...)
Affinity DataIC50: 6.70nMAssay Description:Inhibition of human N-terminal GST-tagged PLK4 (1 to 391 residues) expressed in Escherichia coli incubated for 30 mins by ELISA methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK4(Human)
Entremed

Curated by ChEMBL
LigandPNGBDBM50044667(CHEMBL3353362 | US9907800, Example A58 | US1035843...)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of PLK4 (unknown origin) by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK4(Human)
Entremed

Curated by ChEMBL
LigandPNGBDBM50044667(CHEMBL3353362 | US9907800, Example A58 | US1035843...)
Affinity DataIC50: 100nMAssay Description:PLK4 activity was measured using an indirect ELISA detection system. Dephosphorylated GST-PLK4 (4 nM) was incubated in the presence of 15 μM ATP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2020
Entry Details
Go to US Patent

TargetAurora kinase B(Human)
Entremed

Curated by ChEMBL
LigandPNGBDBM50044667(CHEMBL3353362 | US9907800, Example A58 | US1035843...)
Affinity DataIC50: 550nMAssay Description:Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2020
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase PLK4(Human)
Entremed

Curated by ChEMBL
LigandPNGBDBM50044667(CHEMBL3353362 | US9907800, Example A58 | US1035843...)
Affinity DataIC50: 100nMAssay Description:PLK4 activity was measured using an indirect ELISA detection system. Dephosphorylated GST-PLK4 (4 nM) was incubated in the presence of 15 μM ATP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2020
Entry Details
Go to US Patent

TargetAurora kinase B(Human)
Entremed

Curated by ChEMBL
LigandPNGBDBM50044667(CHEMBL3353362 | US9907800, Example A58 | US1035843...)
Affinity DataIC50: 100nMAssay Description:Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2020
Entry Details
Go to US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Entremed

Curated by ChEMBL
LigandPNGBDBM50044667(CHEMBL3353362 | US9907800, Example A58 | US1035843...)
Affinity DataIC50: 100nMAssay Description:The enzymatic activity of FLT3 was determined using the Z-Lyte assay kit from Invitrogen (Invitrogen cat #PV3191). The assay was performed using the ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/27/2020
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase PLK4 [1-391](Human)
University Health Network

US Patent
LigandPNGBDBM50044667(CHEMBL3353362 | US9907800, Example A58 | US1035843...)
Affinity DataIC50: 100nMAssay Description:Active PLK4 was purified from an E. coli expression system as an amino terminal GST fusion of residues 1-391 of human PLK4. The protein was purified ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetAurora kinase A(Human)
University Health Network

US Patent
LigandPNGBDBM50044667(CHEMBL3353362 | US9907800, Example A58 | US1035843...)
Affinity DataIC50: 500nMAssay Description:Aurora A inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetAurora kinase B(Human)
Entremed

Curated by ChEMBL
LigandPNGBDBM50044667(CHEMBL3353362 | US9907800, Example A58 | US1035843...)
Affinity DataIC50: 100nMAssay Description:Aurora B inhibition was determined using the Z-Lyte assay kit from Invitrogen. The assay was performed using the recommended manufacturer's instr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent

TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Entremed

Curated by ChEMBL
LigandPNGBDBM50044667(CHEMBL3353362 | US9907800, Example A58 | US1035843...)
Affinity DataIC50: 100nMAssay Description:PLK3 inhibition was determined using the Z-Lyte assay kit from Invitrogen (cat #PV3802). The assay was performed using the recommended manufacturer&#...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2020
Entry Details
Go to US Patent