BDBM50044080 2-Amino-5-[1-(3,5-di-tert-butyl-4-hydroxy-phenyl)-meth-(Z)-ylidene]-thiazol-4-one; compound with methanesulfonic acid::CHEMBL109745::CHEMBL196996::CHEMBL275835::Darbufelone mesylate

SMILES CC(C)(C)c1cc(C=C2SC(N)=NC2=O)cc(c1O)C(C)(C)C

InChI Key InChIKey=AKTXOQVMWSFEBQ-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50044080   

TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50044080(CHEMBL196996 | 2-Amino-5-[1-(3,5-di-tert-butyl-4-h...)
Affinity DataIC50: 770nMAssay Description:Inhibition of 5-lipoxygenase in intact rat basophilic leukemia cells stimulated with the calcium ionophore A-23187More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Human)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50044080(CHEMBL196996 | 2-Amino-5-[1-(3,5-di-tert-butyl-4-h...)
Affinity DataIC50: 600nMAssay Description:IC50 against Prostaglandin G/H synthase 1 from human platelet rich plasmaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50044080(CHEMBL196996 | 2-Amino-5-[1-(3,5-di-tert-butyl-4-h...)
Affinity DataIC50: 69nMAssay Description:IC50 value was determined against Prostaglandin G/H synthase 2 of J7744A.1 cell lines.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1/2(Human)
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50044080(CHEMBL196996 | 2-Amino-5-[1-(3,5-di-tert-butyl-4-h...)
Affinity DataIC50: 390nMAssay Description:Inhibitory concentration against prostaglandin G/H synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Rabbit)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50044080(CHEMBL196996 | 2-Amino-5-[1-(3,5-di-tert-butyl-4-h...)
Affinity DataIC50: 3.76E+4nMAssay Description:Inhibition of COX-1 in rabbit peripheral venous blood assessed as formation of 12-hydroxyheptadecatrienoic acid after 24 hrs by HPLC in presence of c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Rabbit)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50044080(CHEMBL196996 | 2-Amino-5-[1-(3,5-di-tert-butyl-4-h...)
Affinity DataIC50: 110nMAssay Description:Inhibition of COX-2 in rabbit peripheral venous blood assessed as formation of 12-hydroxyheptadecatrienoic acid after 24 hrs in by HPLC presence of c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50044080(CHEMBL196996 | 2-Amino-5-[1-(3,5-di-tert-butyl-4-h...)
Affinity DataIC50: 770nMAssay Description:Inhibitory concentration against arachidonate 5-lipoxygenaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2012
Entry Details Article
PubMed