BDBM50043693 CHEMBL3355541::US10047093, 8-67::US10392392, Example 8-67::US10875864, EX. 8-67::US9416132, 8-67

SMILES CN1CCC(CNc2ccn3ncc(-c4cccc(OC(F)(F)F)c4)c3n2)CC1

InChI Key InChIKey=RXIOLPKAVOQIOE-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50043693   

TargetSerine/threonine-protein kinase pim-1(Human)
Tolero Pharmaceuticals

US Patent
LigandPNGBDBM50043693(US10047093, 8-67 | CHEMBL3355541 | US9416132, 8-67...)
Affinity DataIC50: 45nMT: 2°CAssay Description:These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
Tolero Pharmaceuticals

US Patent
LigandPNGBDBM50043693(US10047093, 8-67 | CHEMBL3355541 | US9416132, 8-67...)
Affinity DataIC50: 45nMAssay Description:Inhibition of Pim1 (unknown origin) using luciferase-luciferin based ATP detection reagent by Kinase-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2016
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043693(US10047093, 8-67 | CHEMBL3355541 | US9416132, 8-67...)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells by automated patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043693(US10047093, 8-67 | CHEMBL3355541 | US9416132, 8-67...)
Affinity DataIC50: 1.49E+3nMAssay Description:Inhibition of Pim2 (unknown origin) using luciferase-luciferin based ATP detection reagent by Kinase-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Tolero Pharmaceuticals

US Patent
LigandPNGBDBM50043693(US10047093, 8-67 | CHEMBL3355541 | US9416132, 8-67...)
Affinity DataIC50: 45nMT: 2°CAssay Description:One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2018
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
Tolero Pharmaceuticals

US Patent
LigandPNGBDBM50043693(US10047093, 8-67 | CHEMBL3355541 | US9416132, 8-67...)
Affinity DataIC50: 45nMAssay Description:One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2020
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
Tolero Pharmaceuticals

US Patent
LigandPNGBDBM50043693(US10047093, 8-67 | CHEMBL3355541 | US9416132, 8-67...)
Affinity DataIC50: 45nMAssay Description:One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
Go to US Patent