BDBM50043674 CHEMBL3355550::US10047093, 8-54::US10392392, Example 8-54::US10875864, EX. 8-54::US9416132, 8-54

SMILES O[C@H]1CC[C@@H](CC1)Nc1ccn2ncc(-c3cccc(c3)C(F)(F)F)c2n1

InChI Key InChIKey=DFHQXRLKAFZKPB-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50043674   

TargetSerine/threonine-protein kinase pim-1(Human)
Tolero Pharmaceuticals

US Patent
LigandPNGBDBM50043674(US10047093, 8-54 | CHEMBL3355550 | US9416132, 8-54...)
Affinity DataIC50: 25nMT: 2°CAssay Description:These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Tolero Pharmaceuticals

US Patent
LigandPNGBDBM50043674(US10047093, 8-54 | CHEMBL3355550 | US9416132, 8-54...)
Affinity DataIC50: 3.00E+4nMAssay Description:Representative compounds were tested for hERG activity using the Fast Patch assay available from WuXiApptec (Shanghai China).More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
Tolero Pharmaceuticals

US Patent
LigandPNGBDBM50043674(US10047093, 8-54 | CHEMBL3355550 | US9416132, 8-54...)
Affinity DataIC50: 25nMAssay Description:Inhibition of Pim1 (unknown origin) using luciferase-luciferin based ATP detection reagent by Kinase-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2016
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043674(US10047093, 8-54 | CHEMBL3355550 | US9416132, 8-54...)
Affinity DataIC50: 53nMAssay Description:Inhibition of human Flt3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2016
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Tolero Pharmaceuticals

US Patent
LigandPNGBDBM50043674(US10047093, 8-54 | CHEMBL3355550 | US9416132, 8-54...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells by automated patch clamp methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043674(US10047093, 8-54 | CHEMBL3355550 | US9416132, 8-54...)
Affinity DataIC50: 282nMAssay Description:Inhibition of Pim2 (unknown origin) using luciferase-luciferin based ATP detection reagent by Kinase-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Tolero Pharmaceuticals

US Patent
LigandPNGBDBM50043674(US10047093, 8-54 | CHEMBL3355550 | US9416132, 8-54...)
Affinity DataIC50: 25nMT: 2°CAssay Description:One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2018
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Tolero Pharmaceuticals

US Patent
LigandPNGBDBM50043674(US10047093, 8-54 | CHEMBL3355550 | US9416132, 8-54...)
Affinity DataIC50: 3.00E+4nMAssay Description:Representative compounds were tested for hERG activity using the Fast Patch assay available from WuXiApptec (Shanghai China).More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2018
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
Tolero Pharmaceuticals

US Patent
LigandPNGBDBM50043674(US10047093, 8-54 | CHEMBL3355550 | US9416132, 8-54...)
Affinity DataIC50: 25nMAssay Description:One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2020
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Tolero Pharmaceuticals

US Patent
LigandPNGBDBM50043674(US10047093, 8-54 | CHEMBL3355550 | US9416132, 8-54...)
Affinity DataIC50: 3.00E+4nMAssay Description:hERG activity assays representative compounds were tested for hERG activity using the Fast Patch assay available from WuXiApptec (Shanghai China). More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2020
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
Tolero Pharmaceuticals

US Patent
LigandPNGBDBM50043674(US10047093, 8-54 | CHEMBL3355550 | US9416132, 8-54...)
Affinity DataIC50: 25nMAssay Description:One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Tolero Pharmaceuticals

US Patent
LigandPNGBDBM50043674(US10047093, 8-54 | CHEMBL3355550 | US9416132, 8-54...)
Affinity DataIC50: 3.00E+4nMAssay Description:Representative compounds were tested for hERG activity using the Fast Patch assay available from WuXiApptec (Shanghai China). More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
Go to US Patent