BDBM50043655 CHEMBL3355557::US10047093, 8-95::US10392392, Example 8-95::US10875864, EX. 8-95::US9416132, 8-95

SMILES N[C@H]1CC[C@@H](CC1)Nc1ccn2ncc(-c3cccc(Cl)c3)c2n1

InChI Key InChIKey=QLPGKDRTCLALRP-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50043655   

TargetSerine/threonine-protein kinase pim-1(Human)
Tolero Pharmaceuticals

US Patent
LigandPNGBDBM50043655(US10047093, 8-95 | CHEMBL3355557 | US9416132, 8-95...)
Affinity DataIC50: 24nMT: 2°CAssay Description:These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
Tolero Pharmaceuticals

US Patent
LigandPNGBDBM50043655(US10047093, 8-95 | CHEMBL3355557 | US9416132, 8-95...)
Affinity DataIC50: 24nMT: 2°CAssay Description:These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2017
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
Tolero Pharmaceuticals

US Patent
LigandPNGBDBM50043655(US10047093, 8-95 | CHEMBL3355557 | US9416132, 8-95...)
Affinity DataIC50: 24nMAssay Description:Inhibition of Pim1 (unknown origin) using luciferase-luciferin based ATP detection reagent by Kinase-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-2(Human)
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043655(US10047093, 8-95 | CHEMBL3355557 | US9416132, 8-95...)
Affinity DataIC50: 732nMAssay Description:Inhibition of Pim2 (unknown origin) using luciferase-luciferin based ATP detection reagent by Kinase-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Tolero Pharmaceuticals

US Patent
LigandPNGBDBM50043655(US10047093, 8-95 | CHEMBL3355557 | US9416132, 8-95...)
Affinity DataIC50: 24nMT: 2°CAssay Description:One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2018
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
Tolero Pharmaceuticals

US Patent
LigandPNGBDBM50043655(US10047093, 8-95 | CHEMBL3355557 | US9416132, 8-95...)
Affinity DataIC50: 24nMT: 2°CAssay Description:One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2018
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
Tolero Pharmaceuticals

US Patent
LigandPNGBDBM50043655(US10047093, 8-95 | CHEMBL3355557 | US9416132, 8-95...)
Affinity DataIC50: 24nMAssay Description:One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2020
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
Tolero Pharmaceuticals

US Patent
LigandPNGBDBM50043655(US10047093, 8-95 | CHEMBL3355557 | US9416132, 8-95...)
Affinity DataIC50: 24nMAssay Description:One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/20/2020
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
Tolero Pharmaceuticals

US Patent
LigandPNGBDBM50043655(US10047093, 8-95 | CHEMBL3355557 | US9416132, 8-95...)
Affinity DataIC50: 24nMAssay Description:One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase pim-1(Human)
Tolero Pharmaceuticals

US Patent
LigandPNGBDBM50043655(US10047093, 8-95 | CHEMBL3355557 | US9416132, 8-95...)
Affinity DataIC50: 24nMAssay Description:One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2021
Entry Details
Go to US Patent