BDBM50043510 CHEMBL3355507

SMILES CCN(Cc1ccccc1)C(=O)c1ccc(cc1)S(=O)(=O)Nc1ccccc1

InChI Key InChIKey=HSFGCMJKYHQRQQ-UHFFFAOYSA-N

Data  5 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50043510   

TargetLIM domain kinase 2(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043510(CHEMBL3355507)
Affinity DataIC50: 3nMAssay Description:Inhibition of human full-length LIMK2 expressed in Sf9 cells assessed as incorporation of [33P] from ATP into biotinylated-cofilin substrate in prese...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2016
Entry Details Article
PubMed
TargetLIM domain kinase 1(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50043510(CHEMBL3355507)
Affinity DataIC50: 170nMAssay Description:Inhibition of recombinant LIMK1 (330 to 637 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 105 mins by Rapi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 2(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043510(CHEMBL3355507)
Affinity DataIC50: 13nMAssay Description:Inhibition of recombinant LIMK2 (347 to 659 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 180 mins by Rapi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 1(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50043510(CHEMBL3355507)
Affinity DataIC50: 56nMAssay Description:Inhibition of PAK mediated recombinant LIMK1 phosphorylation (330 to 637 residues) (unknown origin) incubated for 45 mins followed by ATP addition me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 2(Human)
Lexicon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043510(CHEMBL3355507)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of PAK mediated recombinant LIMK2 phosphorylation (347 to 659 residues) (unknown origin) incubated for 45 mins followed by ATP addition me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed
TargetLIM domain kinase 1(Human)
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50043510(CHEMBL3355507)
Affinity DataKd:  53nMAssay Description:Binding affinity to recombinant LIMK1 (330 to 637 residues) (unknown origin) expressed in baculovirus infected insect cells assessed as dissociation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/20/2023
Entry Details
PubMed