BDBM50043285 CHEMBL3355041

SMILES COc1cc2ncnc(Nc3ccc4N(CCc4c3)C(=O)Cn3c(C)cc4ccc(F)cc34)c2cc1OC

InChI Key InChIKey=XXCYJMYHDLAATR-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50043285   

TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
Dart Neuroscience

Curated by ChEMBL

LigandBDBM50043285(CHEMBL3355041)Copy SMILESCopy InChI

Affinity DataIC50: 3.20nMAssay Description:Inhibition of recombinant GST-tagged PERK (unknown origin) by LanthaScreen assayMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
3/19/2016
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetEukaryotic translation initiation factor 2-alpha kinase 3(Human)
Dart Neuroscience

Curated by ChEMBL

LigandBDBM50043285(CHEMBL3355041)Copy SMILESCopy InChI

Affinity DataIC50: 79nMAssay Description:Inhibition of PERK (unknown origin) expressed in HEK293 cells assessed as inhibition of phosphorylation of GFP-eIF2 alpha by cell-based TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
3/19/2016
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL