BDBM50043021 CHEMBL3355031::US9718825, Example 140

SMILES COc1nc(nc2[nH]ncc12)-c1ccc(NS(=O)(=O)c2cc(C)ccc2F)cc1

InChI Key InChIKey=FZDJPIKBPRASNV-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50043021   

TargetSerine/threonine-protein kinase Sgk1(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50043021(CHEMBL3355031 | US9718825, Example 140)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of SGK1 (unknown origin) assessed as substrate phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Sgk1(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50043021(CHEMBL3355031 | US9718825, Example 140)
Affinity DataIC50: 50nMAssay Description:Inhibition of recombinant SGK1 (unknown origin) expressed in U2OS cells by cellular activity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Sgk1(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50043021(CHEMBL3355031 | US9718825, Example 140)
Affinity DataIC50: 18nMpH: 7.4Assay Description:The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2018
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase Sgk1(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50043021(CHEMBL3355031 | US9718825, Example 140)
Affinity DataIC50: 1.5nMpH: 7.4Assay Description:The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2018
Entry Details
Go to US Patent