BDBM50043019 CHEMBL3355029

SMILES O[C@H]1CC[C@@H](CC1)Oc1nc(nc2[nH]ncc12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2F)cc1

InChI Key InChIKey=IKBMUGXVSJZWGW-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50043019   

TargetSerine/threonine-protein kinase Sgk1(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50043019(CHEMBL3355029)
Affinity DataIC50: 120nMAssay Description:Inhibition of recombinant SGK1 (unknown origin) expressed in U2OS cells by cellular activity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Sgk1(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50043019(CHEMBL3355029)
Affinity DataIC50: 1.5nMAssay Description:Inhibition of SGK1 (unknown origin) assessed as substrate phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2016
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Sanofi R&D

Curated by ChEMBL
LigandPNGBDBM50043019(CHEMBL3355029)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate incubated for 30 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Sgk1(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50043019(CHEMBL3355029)
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant human SGK1 expressed in baculovirus expression system using 5-carboxyfluorescein -RPRAATF-NH2 as substrate preincubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Sgk1(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50043019(CHEMBL3355029)
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant human SGK1 expressed in baculovirus expression system using 5-carboxyfluorescein -RPRAATF-NH2 as substrate preincubated for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Sgk1(Mouse)
Sanofi R&D

Curated by ChEMBL
LigandPNGBDBM50043019(CHEMBL3355029)
Affinity DataIC50: 253nMAssay Description:Inhibition of mouse SGK1 in presence 500 uM presence of ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Sanofi R&D

Curated by ChEMBL
LigandPNGBDBM50043019(CHEMBL3355029)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate incubated for 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details Article
PubMed