BDBM50042976 (E)-3-Phenyl-1-(2,4,6-trihydroxy-phenyl)-propenone::(E)-3-phenyl-1-(2,4,6-trihydroxyphenyl)prop-2-en-1-one::2',4',6'-trihydroxychalcone::3-Phenyl-1-(2,4,6-trihydroxy-phenyl)-propenone::CHEMBL129371

SMILES Oc1cc(O)c(C(=O)\C=C\c2ccccc2)c(O)c1

InChI Key InChIKey=LOYXTWZXLWHMBX-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50042976   

TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50042976(2',4',6'-trihydroxychalcone | (E)-3-phenyl-1-(2,4,...)
Affinity DataIC50: 1.40E+5nMAssay Description:In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyphenol oxidase 2(White button mushroom)
Hokkaido University

Curated by ChEMBL
LigandPNGBDBM50042976(2',4',6'-trihydroxychalcone | (E)-3-phenyl-1-(2,4,...)
Affinity DataIC50: 1.20E+5nMAssay Description:Inhibition of mushroom tyrosinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
Tokushima Bunri University

Curated by ChEMBL
LigandPNGBDBM50042976(2',4',6'-trihydroxychalcone | (E)-3-phenyl-1-(2,4,...)
Affinity DataIC50: 1.40E+5nMAssay Description:Inhibition of 5-lipoxygenase in rat RBL1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article

TargetSodium/glucose cotransporter 2(Human)
Universidade De Lisboa

Curated by ChEMBL
LigandPNGBDBM50042976(2',4',6'-trihydroxychalcone | (E)-3-phenyl-1-(2,4,...)
Affinity DataIC50: 3.33E+4nMAssay Description:Inhibition of human SGLT2 expressed in HEK293 cells assessed as reduction in 2-deoxyglucose uptake pretreated for 10 mins followed by 2-deoxyglucose ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2019
Entry Details Article
PubMed
TargetSodium/glucose cotransporter 1(Human)
Universidade De Lisboa

Curated by ChEMBL
LigandPNGBDBM50042976(2',4',6'-trihydroxychalcone | (E)-3-phenyl-1-(2,4,...)
Affinity DataIC50: 2.54E+4nMAssay Description:Inhibition of human SGLT1 expressed in HEK293 cells assessed as reduction in 2-deoxyglucose uptake pretreated for 10 mins followed by 2-deoxyglucose ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2019
Entry Details Article
PubMed