BDBM50042498 CHEMBL333219::N-{[6-(4-fluorophenoxy)-2H-chromen-3-yl]methyl}-N-hydroxy-N'-methylurea

SMILES CNC(=O)N(O)CC1=Cc2cc(Oc3ccc(F)cc3)ccc2OC1

InChI Key InChIKey=SOEOWQASEQWFFZ-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50042498   

LigandPNGBDBM50042498(N-{[6-(4-fluorophenoxy)-2H-chromen-3-yl]methyl}-N-...)
Affinity DataIC50: 410nMAssay Description:Inhibitory concentration against human platelet 12-lipoxygenaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50042498(N-{[6-(4-fluorophenoxy)-2H-chromen-3-yl]methyl}-N-...)
Affinity DataIC50: 410nMAssay Description:Inhibitory concentration against human platelet 5-lipoxygenase in human whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetThromboxane-A synthase(Rat)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50042498(N-{[6-(4-fluorophenoxy)-2H-chromen-3-yl]methyl}-N-...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibitory concentration against human platelet thromboxane synthetaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1/2(Sheep)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50042498(N-{[6-(4-fluorophenoxy)-2H-chromen-3-yl]methyl}-N-...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory concentration against sheep seminal vesicle Prostaglandin G/H synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50042498(N-{[6-(4-fluorophenoxy)-2H-chromen-3-yl]methyl}-N-...)
Affinity DataIC50: 45nMAssay Description:In vitro inhibitory activity against 5-lipoxygenase by reduction of 5-hydroxyeicosatetraenoic acid (5-HETE) formed in guinea pig polymorphonuclear le...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50042498(N-{[6-(4-fluorophenoxy)-2H-chromen-3-yl]methyl}-N-...)
Affinity DataIC50: 51nMAssay Description:In vitro inhibitory activity against 5-lipoxygenase by reduction of LTB4 formed in guinea pig polymorphonuclear leukocytes (PMNs).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50042498(N-{[6-(4-fluorophenoxy)-2H-chromen-3-yl]methyl}-N-...)
Affinity DataIC50: 110nMAssay Description:Inhibitory concentration against human platelet 5-lipoxygenase in dog whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed