BDBM500421 7-[(5-piperazin-1-yl- 2-pyridyl)amino]- 4-(5,6,7,8- tetrahydro- imidazo[1,2- a]pyridin-3- yl)isoindolin- 1-one::US11021481, Compound I-80::US11078201, Compound I-80::US11548890, Compound I-80

SMILES O=C1NCc2c1c(Nc1ccc(cn1)N1CCNCC1)ccc2-c1cnc2CCCCn12

InChI Key InChIKey=WNSLIPBXSGXMSD-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 500421   

LigandPNGBDBM500421(US11021481, Compound I-80 | 7-[(5-piperazin-1-yl- ...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
Go to US Patent

LigandPNGBDBM500421(US11021481, Compound I-80 | 7-[(5-piperazin-1-yl- ...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
Go to US Patent

LigandPNGBDBM500421(US11021481, Compound I-80 | 7-[(5-piperazin-1-yl- ...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
Go to US Patent

LigandPNGBDBM500421(US11021481, Compound I-80 | 7-[(5-piperazin-1-yl- ...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
Go to US Patent

LigandPNGBDBM500421(US11021481, Compound I-80 | 7-[(5-piperazin-1-yl- ...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details
Go to US Patent