BDBM50042056 (R)-4-(3-Cyclopentyloxy-4-methoxy-phenyl)-pyrrolidin-2-one::CHEMBL325795

SMILES COc1ccc(cc1OC1CCCC1)[C@H]1CNC(=O)C1

InChI Key InChIKey=HJORMJIFDVBMOB-UHFFFAOYSA-N

Data  6 IC50  1 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50042056   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
University of Glasgow

Curated by ChEMBL
LigandPNGBDBM50042056((R)-4-(3-Cyclopentyloxy-4-methoxy-phenyl)-pyrrolid...)
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of full-length PDE4A4 using cAMP as substrate by two-step radiochemical assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
University of Glasgow

Curated by ChEMBL
LigandPNGBDBM50042056((R)-4-(3-Cyclopentyloxy-4-methoxy-phenyl)-pyrrolid...)
Affinity DataEC50:  3.40E+3nMAssay Description:Induction of SQSTM1-dependent intracellular redistribution of GFP-tagged PDE4A4 assessed as maximal accretion of enzyme into fociMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50042056((R)-4-(3-Cyclopentyloxy-4-methoxy-phenyl)-pyrrolid...)
Affinity DataIC50: 1.06E+3nMAssay Description:Inhibition of PDE4D2 catalytic domain (86 to 413 residues) (unknown origin) using [3H]-cAMP as substrate after 15 mins by liquid scintillation counti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2017
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Sun Yat-Sen University

Curated by ChEMBL
LigandPNGBDBM50042056((R)-4-(3-Cyclopentyloxy-4-methoxy-phenyl)-pyrrolid...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of PDE4D2 catalytic domain (86 to 413 residues) (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2017
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50042056((R)-4-(3-Cyclopentyloxy-4-methoxy-phenyl)-pyrrolid...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of partially-purified PDE 4 from human monocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2019
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50042056((R)-4-(3-Cyclopentyloxy-4-methoxy-phenyl)-pyrrolid...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition activity against human monocyte derived PDE4 catalytic activity (LPDE4)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50042056((R)-4-(3-Cyclopentyloxy-4-methoxy-phenyl)-pyrrolid...)
Affinity DataIC50: 45nMAssay Description:Competition of [3H]rolipram binding sites in the central nervous system (HPDE4) in rat brain cytosolMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed
TargetVascular endothelial growth factor A(Human)
University Paris Cite

Curated by ChEMBL
LigandPNGBDBM50042056((R)-4-(3-Cyclopentyloxy-4-methoxy-phenyl)-pyrrolid...)
Affinity DataKd:  0.660nMAssay Description:Binding affinity to human VEGF (13 to 107 residues) expressed in Escherichia coli Rosetta (DE3) cells assessed as dissociation constant at 20 degreeC...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMed