BDBM500415 3-[7-[[5-(4- methylpiperazin- 1-yl)-2- pyridyl]amino]- 1-oxo- isoindolin-4- yl]imidazo[1,2- a]pyridine-8- carbonitrile::US11021481, Compound I-74::US11078201, Compound I-74::US11548890, Compound I-74

SMILES CN1CCN(CC1)c1ccc(Nc2ccc(c3CNC(=O)c23)-c2cnc3c(cccn23)C#N)nc1

InChI Key InChIKey=YSDYINCLAOQGOF-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 500415   

LigandPNGBDBM500415(US11021481, Compound I-74 | 3-[7-[[5-(4- methylpip...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
Go to US Patent

LigandPNGBDBM500415(US11021481, Compound I-74 | 3-[7-[[5-(4- methylpip...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
Go to US Patent

LigandPNGBDBM500415(US11021481, Compound I-74 | 3-[7-[[5-(4- methylpip...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
Go to US Patent

LigandPNGBDBM500415(US11021481, Compound I-74 | 3-[7-[[5-(4- methylpip...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
Go to US Patent

LigandPNGBDBM500415(US11021481, Compound I-74 | 3-[7-[[5-(4- methylpip...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details
Go to US Patent