BDBM50040923 2-Methyl-5,6-bis-phenylamino-isoindole-1,3-dione::CHEMBL8036::N-Methyl-4,5-dianilinophthalimide

SMILES CN1C(=O)c2cc(Nc3ccccc3)c(Nc3ccccc3)cc2C1=O

InChI Key InChIKey=TVXMUKJNBYIOBU-UHFFFAOYSA-N

Data  1 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50040923   

TargetEpidermal growth factor receptor(Human)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50040923(N-Methyl-4,5-dianilinophthalimide | 2-Methyl-5,6-b...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of EGF-dependent autophosphorylation of EGF-R in human A431 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50040923(N-Methyl-4,5-dianilinophthalimide | 2-Methyl-5,6-b...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibitory activity against recombinant tyrosine kinase EGF-R (EGF-R ICD)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50040923(N-Methyl-4,5-dianilinophthalimide | 2-Methyl-5,6-b...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of PDGF-dependent autophosphorylation of PDGF-R in mouse BALB/c3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetcAMP-dependent protein kinase(Rabbit)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50040923(N-Methyl-4,5-dianilinophthalimide | 2-Methyl-5,6-b...)
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibitory activity was determined against protein kinase A (PKA) of rabbitMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50040923(N-Methyl-4,5-dianilinophthalimide | 2-Methyl-5,6-b...)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [125I-N-Methyl-4-(4-bromoanilino)phthalimide from beta-amyloid plaques isolated from Alzheimer's disease patient brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2020
Entry Details Article
PubMed