BDBM50040794 CHEMBL3353194::US10544133, Example 22::US9657009, 22

SMILES CC(C)Nc1cc(ncc1C(=O)NC[C@H](C(C)(C)O)F)Nc2ncc(cn2)C#N

InChI Key InChIKey=UFIWUTUQZFYHKK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50040794   

TargetInterleukin-1 receptor-associated kinase 4(Human)
Nimbus Discovery

Curated by ChEMBL
LigandPNGBDBM50040794(CHEMBL3353194 | US9657009, 22 | US10544133, Exampl...)
Affinity DataIC50: 5.30nMAssay Description:Inhibition of IRAK4 (unknown origin) using fluoresceinated peptide and ATP after 60 mins by by Caliper assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/18/2016
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Nimbus Discovery

Curated by ChEMBL
LigandPNGBDBM50040794(CHEMBL3353194 | US9657009, 22 | US10544133, Exampl...)
Affinity DataIC50: 5.30nMAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μL prepared from 15 μL additions of enzyme and substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2019
Entry Details
Go to US Patent

TargetInterleukin-1 receptor-associated kinase 4(Human)
Nimbus Discovery

Curated by ChEMBL
LigandPNGBDBM50040794(CHEMBL3353194 | US9657009, 22 | US10544133, Exampl...)
Affinity DataIC50: 5.30nMAssay Description:The assays were performed in U-bottom 384-well plates. The final assay volume was 30 μL prepared from 15 μL additions of enzyme and substra...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/2/2020
Entry Details
Go to US Patent