BDBM50040439 2,4-Dimethyl-8-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-5,8-dihydro-6H-pyrido[2,3-d]pyrimidin-7-one::2,4-Dimethyl-8-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-5,8-dihydro-6H-pyrido[2,3-d]pyrimidin-7-one::CHEMBL432162

SMILES Cc1nc(C)c2CCC(=O)N(Cc3ccc(cc3)-c3ccccc3-c3nnn[nH]3)c2n1

InChI Key InChIKey=ADXGNEYLLLSOAR-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50040439   

TargetType-1 angiotensin II receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50040439(2,4-Dimethyl-8-[2'-(2H-tetrazol-5-yl)-biphenyl-4-y...)
Affinity DataIC50: 38nMAssay Description:Compound was tested in vitro for inhibitory activity against human Angiotensin II receptor in cultured preadipocytesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50040439(2,4-Dimethyl-8-[2'-(2H-tetrazol-5-yl)-biphenyl-4-y...)
Affinity DataIC50: 32nMAssay Description:Compound was tested for inhibition against Angiotensin II receptor, type 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor A/B(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50040439(2,4-Dimethyl-8-[2'-(2H-tetrazol-5-yl)-biphenyl-4-y...)
Affinity DataIC50: 5.20nMAssay Description:In vitro inhibition of specific binding of [125 I] A II to rat liver membrane.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetType-1 angiotensin II receptor A/B(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50040439(2,4-Dimethyl-8-[2'-(2H-tetrazol-5-yl)-biphenyl-4-y...)
Affinity DataIC50: 1.20nMAssay Description:Compound was evaluated for the in vitro inhibition of specific binding of [125I]-A II to Angiotensin II receptor, type 1 from rat adrenal membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/22/2020
Entry Details Article
PubMed