BDBM50040345 CHEMBL146165::N-(1,3-Bis-cyclopropylmethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)-4-methoxy-benzenesulfonamide

SMILES COc1ccc(cc1)S(=O)(=O)Nc1nc2n(CC3CC3)c(=O)n(CC3CC3)c(=O)c2[nH]1

InChI Key InChIKey=RTXKFCUSZPJMRA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50040345   

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50040345(N-(1,3-Bis-cyclopropylmethyl-2,6-dioxo-2,3,6,7-tet...)
Affinity DataIC50: 6.80E+4nMAssay Description:Concentration required to inhibit 50% activity of phosphodiesterase VA isoenzyme at 100 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A1(Rat)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50040345(N-(1,3-Bis-cyclopropylmethyl-2,6-dioxo-2,3,6,7-tet...)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of adenosine binding to A1 receptor of rat brain homogenatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed