BDBM500399 4-imidazo[1,2- a]pyridin-3-yl- 7-[[5-[4- (methylamino)- 1-piperidyl]- 2-pyridyl]amino] isoindolin-1-one::US11021481, Compound I-58::US11078201, Compound I-58::US11548890, Compound I-58

SMILES CNC1CCN(CC1)c1ccc(Nc2ccc(c3CNC(=O)c23)-c2cnc3ccccn23)nc1

InChI Key InChIKey=UKGSTFROKJYFMT-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 500399   

LigandPNGBDBM500399(US11021481, Compound I-58 | 4-imidazo[1,2- a]pyrid...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
Go to US Patent

LigandPNGBDBM500399(US11021481, Compound I-58 | 4-imidazo[1,2- a]pyrid...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
Go to US Patent

LigandPNGBDBM500399(US11021481, Compound I-58 | 4-imidazo[1,2- a]pyrid...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
Go to US Patent

LigandPNGBDBM500399(US11021481, Compound I-58 | 4-imidazo[1,2- a]pyrid...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
Go to US Patent

LigandPNGBDBM500399(US11021481, Compound I-58 | 4-imidazo[1,2- a]pyrid...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details
Go to US Patent