BDBM500391 4-(1-ethylpyrrolo]2,3- b]pyridin-4- yl)-7-[[5-(4- methylpiperazin- 1-yl)-2-pyridyl]amino] isoindolin-1-one::US11021481, Compound I-49::US11078201, Compound I-49::US11548890, Compound I-49

SMILES CCn1ccc2c(ccnc12)-c1ccc(Nc2ccc(cn2)N2CCN(C)CC2)c2C(=O)NCc12

InChI Key InChIKey=MLVSNERBXCUPKJ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 500391   

LigandPNGBDBM500391(US11021481, Compound I-49 | 4-(1-ethylpyrrolo]2,3-...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
Go to US Patent

LigandPNGBDBM500391(US11021481, Compound I-49 | 4-(1-ethylpyrrolo]2,3-...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
Go to US Patent

LigandPNGBDBM500391(US11021481, Compound I-49 | 4-(1-ethylpyrrolo]2,3-...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
Go to US Patent

LigandPNGBDBM500391(US11021481, Compound I-49 | 4-(1-ethylpyrrolo]2,3-...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
Go to US Patent

LigandPNGBDBM500391(US11021481, Compound I-49 | 4-(1-ethylpyrrolo]2,3-...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details
Go to US Patent