BDBM500385 4-(1-methylpyrrolo] 2,3-b]pyridin- 4-yl)-7-[(5- piperazin-1-yl- 2-pyridyl)amino] isoindolin-1-one::US11021481, Compound I-43::US11021481, Compound I-93::US11021481, Compound I-96::US11078201, Compound I-96::US11548890, Compound I-98

SMILES Cn1ccc2c(ccnc12)-c1ccc(Nc2ccc(cn2)N2CCNCC2)c2C(=O)NCc12

InChI Key InChIKey=IXKKCRQRHQQLND-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 500385   

LigandPNGBDBM500385(4-(1-methylpyrrolo] 2,3-b]pyridin- 4-yl)-7-[(5- pi...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
Go to US Patent

LigandPNGBDBM500385(4-(1-methylpyrrolo] 2,3-b]pyridin- 4-yl)-7-[(5- pi...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
Go to US Patent

LigandPNGBDBM500385(4-(1-methylpyrrolo] 2,3-b]pyridin- 4-yl)-7-[(5- pi...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
Go to US Patent

LigandPNGBDBM500385(4-(1-methylpyrrolo] 2,3-b]pyridin- 4-yl)-7-[(5- pi...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
Go to US Patent

LigandPNGBDBM500385(4-(1-methylpyrrolo] 2,3-b]pyridin- 4-yl)-7-[(5- pi...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
Go to US Patent

LigandPNGBDBM500385(4-(1-methylpyrrolo] 2,3-b]pyridin- 4-yl)-7-[(5- pi...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
Go to US Patent

LigandPNGBDBM500385(4-(1-methylpyrrolo] 2,3-b]pyridin- 4-yl)-7-[(5- pi...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
Go to US Patent

LigandPNGBDBM500385(4-(1-methylpyrrolo] 2,3-b]pyridin- 4-yl)-7-[(5- pi...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details
Go to US Patent

LigandPNGBDBM500385(4-(1-methylpyrrolo] 2,3-b]pyridin- 4-yl)-7-[(5- pi...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details
Go to US Patent