BDBM50038473 CHEMBL3354844::US9216981, 18

SMILES Fc1ccc(NS(=O)(=O)c2ccoc2)c(F)c1Nc1ncccc1-c1ncnc2[nH]cnc12

InChI Key InChIKey=ACIXGVIVJZJKNT-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50038473   

TargetSerine/threonine-protein kinase B-raf(Human)
Medpacto

US Patent
LigandPNGBDBM50038473(US9216981, 18 | CHEMBL3354844)
Affinity DataIC50: 1nMpH: 7.2 T: 2°CAssay Description:To check the B-Raf kinase inhibitory activity of the compounds of the present invention, the following experiments were conducted.(1) Serial Signalin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2016
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Medpacto

US Patent
LigandPNGBDBM50038473(US9216981, 18 | CHEMBL3354844)
Affinity DataEC50:  2nMT: 2°CAssay Description:To check the B-Raf cell activity inhibitory capability of the compounds of the present invention, the following experiments were conducted in A375P c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2016
Entry Details
Go to US Patent

TargetSerine/threonine-protein kinase B-raf(Human)
Medpacto

US Patent
LigandPNGBDBM50038473(US9216981, 18 | CHEMBL3354844)
Affinity DataIC50: 1nMAssay Description:Inhibition of B-Raf V600E mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2016
Entry Details Article
PubMed