BDBM50037814 2,5-Bis-hydroxymethyl-pyrrolidine-3,4-diol::CHEMBL121093

SMILES C([C@H]1[C@H]([C@@H]([C@H](N1)CO)O)O)O

InChI Key InChIKey=PFYHYHZGDNWFIF-UHFFFAOYSA-N

Data  1 KI  8 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50037814   

TargetTrehalase(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50037814(2,5-Bis-hydroxymethyl-pyrrolidine-3,4-diol | CHEMB...)
Affinity DataIC50: 2.00E+5nMAssay Description:Concentration that causes 50% inhibition of mammalian trehalase was determined in porcine kidneyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2012
Entry Details Article
PubMed
TargetBeta-galactosidase(Bovine)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50037814(2,5-Bis-hydroxymethyl-pyrrolidine-3,4-diol | CHEMB...)
Affinity DataIC50: 3.30E+3nMAssay Description:Concentration that causes 50% inhibition of mammalian cytosolic beta-galactosidase was determined in bovine liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2012
Entry Details Article
PubMed
TargetLysosomal alpha-glucosidase(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50037814(2,5-Bis-hydroxymethyl-pyrrolidine-3,4-diol | CHEMB...)
Affinity DataIC50: 9.20E+4nMAssay Description:Concentration that causes 50% inhibition of mammalian alpha-glucosidase (lysosomal) was determined in rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2012
Entry Details Article
PubMed
TargetBeta-glucosidase A(Caldocellum saccharolyticum)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50037814(2,5-Bis-hydroxymethyl-pyrrolidine-3,4-diol | CHEMB...)
Affinity DataIC50: 3.40E+4nMAssay Description:Concentration that causes 50% inhibition of mammalian cellobiase beta-glucosidase was determined in rat intestineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2012
Entry Details Article
PubMed
TargetBeta-galactosidase(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50037814(2,5-Bis-hydroxymethyl-pyrrolidine-3,4-diol | CHEMB...)
Affinity DataIC50: 3.60E+3nMAssay Description:Concentration that causes 50% inhibition of mammalian lactase beta-galactosidase was determined in rat intestineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2012
Entry Details Article
PubMed
TargetTrehalase(Rat)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50037814(2,5-Bis-hydroxymethyl-pyrrolidine-3,4-diol | CHEMB...)
Affinity DataIC50: 3.60E+5nMAssay Description:Concentration that causes 50% inhibition of mammalian trehalase was determined in rat intestineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2012
Entry Details Article
PubMed
TargetNeutral alpha-glucosidase C(Mouse)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50037814(2,5-Bis-hydroxymethyl-pyrrolidine-3,4-diol | CHEMB...)
Affinity DataIC50: 9.10E+4nMAssay Description:Concentration that causes 50% inhibition of mammalian alpha-glucosidase (isomaltase) was determined in rat intestineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2012
Entry Details Article
PubMed
TargetLysosomal alpha-glucosidase(Bovine)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM50037814(2,5-Bis-hydroxymethyl-pyrrolidine-3,4-diol | CHEMB...)
Affinity DataIC50: 1.70E+5nMAssay Description:Inhibition of mammalian alpha-glucosidase (lysosomal) was determined in bovine liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2012
Entry Details Article
PubMed
TargetTissue alpha-L-fucosidase(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50037814(2,5-Bis-hydroxymethyl-pyrrolidine-3,4-diol | CHEMB...)
Affinity DataKi:  9.10E+5nMAssay Description:Inhibition constant against Alpha-Fucosidase; Uncompetitive inhibitionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2012
Entry Details Article