BDBM50037483 (+)-cis-N-Normetazocine::(6S,11R)-6,11-Dimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocin-8-ol::CHEMBL114203

SMILES C[C@H]1C2Cc3ccc(O)cc3[C@@]1(C)CCN2

InChI Key InChIKey=DXESFJJJWBHLJX-UHFFFAOYSA-N

Data  5 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50037483   

TargetMas-related G-protein coupled receptor member X2(Human)
University of North Carolina

LigandPNGBDBM50037483((6S,11R)-6,11-Dimethyl-1,2,3,4,5,6-hexahydro-2,6-m...)
Affinity DataEC50:  1.30E+4nMpH: 7.4 T: 2°CAssay Description:MRGPRX2 stable cells were maintained in DMEM containing 10% FBS, 100 μg/ml hygromycin B, and 15 μg/ml blasticidin. For the calcium mobiliza...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2017
Entry Details Article
PubMed
TargetMas-related G-protein coupled receptor member X2(Human)
University of North Carolina

LigandPNGBDBM50037483((6S,11R)-6,11-Dimethyl-1,2,3,4,5,6-hexahydro-2,6-m...)
Affinity DataEC50:  1.40E+4nMpH: 7.4 T: 2°CAssay Description:HTLA cells (HEK-T cells stably expressing a β-arrestin2-TEV fusion protein and a tTa-dependent luciferase reporter) were maintained in DMEM (Cor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2017
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50037483((6S,11R)-6,11-Dimethyl-1,2,3,4,5,6-hexahydro-2,6-m...)
Affinity DataKi:  23nMAssay Description:Inhibition against mu receptor using [3H]DAMGO in homogenate of rat brain cerebellumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50037483((6S,11R)-6,11-Dimethyl-1,2,3,4,5,6-hexahydro-2,6-m...)
Affinity DataKi:  54nMAssay Description:Inhibition against mu receptor from displacement studies using 0.5 nM [3H]-DAMGO in rhesus monkey cortex membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50037483((6S,11R)-6,11-Dimethyl-1,2,3,4,5,6-hexahydro-2,6-m...)
Affinity DataKi:  113nMAssay Description:Inhibition against kappa receptor from displacement studies using 1.5 nM [3H]U-69593 in rhesus monkey cortex membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50037483((6S,11R)-6,11-Dimethyl-1,2,3,4,5,6-hexahydro-2,6-m...)
Affinity DataKi:  449nMAssay Description:Inhibition against delta receptor from displacement studies using 1.5 nM [3H]DPDPE in rhesus monkey cortex membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50037483((6S,11R)-6,11-Dimethyl-1,2,3,4,5,6-hexahydro-2,6-m...)
Affinity DataKi:  6.75E+3nMAssay Description:Inhibition against sigma receptor using displacement of 3 nM [3H]pentazocine in homogenate of guinea pig brain cerebellumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2012
Entry Details Article
PubMed