BDBM50037481 (-)-cis-Normetazocine::(6R,11S)-6,11-Dimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocin-8-ol::CHEMBL326370

SMILES C[C@@H]1C2Cc3ccc(O)cc3[C@]1(C)CCN2

InChI Key InChIKey=DXESFJJJWBHLJX-UHFFFAOYSA-N

Data  5 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50037481   

TargetMas-related G-protein coupled receptor member X2(Human)
University of North Carolina

LigandPNGBDBM50037481((6R,11S)-6,11-Dimethyl-1,2,3,4,5,6-hexahydro-2,6-m...)
Affinity DataEC50:  5.00E+4nMpH: 7.4 T: 2°CAssay Description:HTLA cells (HEK-T cells stably expressing a β-arrestin2-TEV fusion protein and a tTa-dependent luciferase reporter) were maintained in DMEM (Cor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2017
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50037481((6R,11S)-6,11-Dimethyl-1,2,3,4,5,6-hexahydro-2,6-m...)
Affinity DataKi:  470nMAssay Description:Inhibition against mu receptor using [3H]DAMGO in homogenate of rat brain cerebellumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50037481((6R,11S)-6,11-Dimethyl-1,2,3,4,5,6-hexahydro-2,6-m...)
Affinity DataKi:  1.72E+3nMAssay Description:Inhibition against mu receptor from displacement studies using 0.5 nM [3H]-DAMGO in rhesus monkey cortex membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50037481((6R,11S)-6,11-Dimethyl-1,2,3,4,5,6-hexahydro-2,6-m...)
Affinity DataKi:  2.73E+3nMAssay Description:Inhibition against sigma receptor using displacement of 3 nM [3H]pentazocine in homogenate of guinea pig brain cerebellumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50037481((6R,11S)-6,11-Dimethyl-1,2,3,4,5,6-hexahydro-2,6-m...)
Affinity DataKi:  3.78E+3nMAssay Description:Inhibition against kappa receptor from displacement studies using 1.5 nM [3H]U-69593 in rhesus monkey cortex membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50037481((6R,11S)-6,11-Dimethyl-1,2,3,4,5,6-hexahydro-2,6-m...)
Affinity DataKi:  7.00E+3nMAssay Description:Inhibition against delta receptor from displacement studies using 1.5 nM [3H]DPDPE in rhesus monkey cortex membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2012
Entry Details Article
PubMed