BDBM50037134 (+)-trans-3-Cyclopropylmethyl-2,3,4,4aalpha,5,6,7,7aalpha-octahydro-1H-benzo[4,5]furo[3,2-e]isoquinolin-9-ol::(+/-)-trans-3-Cyclopropylmethyl-2,3,4,4aalpha,5,6,7,7aalpha-octahydro-1H-benzo[4,5]furo[3,2-e]isoquinolin-9-ol::(-)-trans-3-Cyclopropylmethyl-2,3,4,4aalpha,5,6,7,7aalpha-octahydro-1H-benzo[4,5]furo[3,2-e]isoquinolin-9-ol::(4aR,7aS,12bS)-3-Cyclopropylmethyl-2,3,4,4a,5,6,7,7a-octahydro-1H-8-oxa-3-aza-benzo[d]fluoren-9-ol::CHEMBL104042

SMILES Oc1cccc2c1O[C@H]1CCC[C@H]3CN(CC4CC4)CC[C@]213

InChI Key InChIKey=SQZBAUUHDXMUTO-UHFFFAOYSA-N

Data  10 KI  2 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50037134   

TargetDelta-type opioid receptor(Human)
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50037134((-)-trans-3-Cyclopropylmethyl-2,3,4,4aalpha,5,6,7,...)
Affinity DataKd:  20nMAssay Description:Binding affinity to human delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50037134((-)-trans-3-Cyclopropylmethyl-2,3,4,4aalpha,5,6,7,...)
Affinity DataKd:  0.220nMAssay Description:Binding affinity to human mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50037134((-)-trans-3-Cyclopropylmethyl-2,3,4,4aalpha,5,6,7,...)
Affinity DataEC50:  2.70nMAssay Description:Partial agonist activity at human kappa opioid receptor expressed in CHO cells assessed as stimulation of [35S]-GTPgammaS binding after 3 hrs by liqu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50037134((-)-trans-3-Cyclopropylmethyl-2,3,4,4aalpha,5,6,7,...)
Affinity DataKi:  0.0800nMAssay Description:Displacement of [125I]OXY from human mu opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50037134((-)-trans-3-Cyclopropylmethyl-2,3,4,4aalpha,5,6,7,...)
Affinity DataKi:  0.100nMAssay Description:Displacement of [125I]OXY from human kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50037134((-)-trans-3-Cyclopropylmethyl-2,3,4,4aalpha,5,6,7,...)
Affinity DataKi:  0.100nMAssay Description:Displacement of [125I]OXY from human kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50037134((-)-trans-3-Cyclopropylmethyl-2,3,4,4aalpha,5,6,7,...)
Affinity DataKi:  0.570nMAssay Description:In vivo binding affinity against mu opioid receptor was measured by using labeled ligand [3H]naloxone (0.5 nM)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50037134((-)-trans-3-Cyclopropylmethyl-2,3,4,4aalpha,5,6,7,...)
Affinity DataKi:  1.20nMAssay Description:In vivo binding affinity against kappa opioid receptor was measured by using labeled ligand [3H]ethylketocyclazocine (1 nM) with 500 nM DADLE and 20 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50037134((-)-trans-3-Cyclopropylmethyl-2,3,4,4aalpha,5,6,7,...)
Affinity DataKi:  2nMAssay Description:Displacement of [125I]OXY from human delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50037134((-)-trans-3-Cyclopropylmethyl-2,3,4,4aalpha,5,6,7,...)
Affinity DataKi:  5.30nMAssay Description:In vivo binding affinity against delta Opioid receptor was measured by using labeled ligand [3H]DADLE (1 nM) with 4 nM sufentanilMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50037134((-)-trans-3-Cyclopropylmethyl-2,3,4,4aalpha,5,6,7,...)
Affinity DataKi:  21nMAssay Description:In vivo binding affinity against sigma Opioid receptor was measured by using labeled ligand [3H]-SKF- 10,047 (1 nM)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50037134((-)-trans-3-Cyclopropylmethyl-2,3,4,4aalpha,5,6,7,...)
Affinity DataKi:  201nMAssay Description:Displacement of [3H](+)-pentazocine from sigma1 receptor in rat brain homogenateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Rat)
National Taiwan University

Curated by ChEMBL
LigandPNGBDBM50037134((-)-trans-3-Cyclopropylmethyl-2,3,4,4aalpha,5,6,7,...)
Affinity DataKi:  201nMAssay Description:Displacement of [3H](+)-pentazocine from sigma1 receptor in rat brain homogenateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed