BDBM50036694 (E)-2-Cyano-3-(4-hydroxy-3-methoxy-5-phenylsulfanylmethyl-phenyl)-acrylamide::2-Cyano-3-(4-hydroxy-3-methoxy-5-phenylsulfanylmethyl-phenyl)-acrylamide::2-cyano-3-(4-hydroxy-3-methoxy-5-(phenylthiomethyl)phenyl)acrylamide::CHEMBL116595

SMILES COc1cc(\C=C(/C#N)C(N)=O)cc(CSc2ccccc2)c1O

InChI Key InChIKey=FOGXCBUSKWTDKV-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50036694   

TargetEpidermal growth factor receptor(Human)
Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50036694(2-Cyano-3-(4-hydroxy-3-methoxy-5-phenylsulfanylmet...)
Affinity DataIC50: 1.25E+4nMAssay Description:Inhibition of HER-14 (human EGFR overexpressing NIH3T3) cell proliferationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor/Receptor tyrosine-protein kinase erbB-2(Human)
Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50036694(2-Cyano-3-(4-hydroxy-3-methoxy-5-phenylsulfanylmet...)
Affinity DataIC50: 130nMAssay Description:Inhibitory concentration against ErbB2/neu (HER-2) by autophosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50036694(2-Cyano-3-(4-hydroxy-3-methoxy-5-phenylsulfanylmet...)
Affinity DataIC50: 500nMAssay Description:Inhibition of EGFR in human A431 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
University of Tennessee Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM50036694(2-Cyano-3-(4-hydroxy-3-methoxy-5-phenylsulfanylmet...)
Affinity DataIC50: 129nMAssay Description:Inhibitory activity tested against protein kinase HER-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50036694(2-Cyano-3-(4-hydroxy-3-methoxy-5-phenylsulfanylmet...)
Affinity DataIC50: 398nMAssay Description:Inhibitory activity against epidermal growth factor receptor (EGFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50036694(2-Cyano-3-(4-hydroxy-3-methoxy-5-phenylsulfanylmet...)
Affinity DataIC50: 400nMAssay Description:Inhibitory concentration against EGF receptor by autophosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50036694(2-Cyano-3-(4-hydroxy-3-methoxy-5-phenylsulfanylmet...)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibitory concentration against EGF receptor by polyGAT phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed