BDBM50036438 1-Methyl-4-(5-methyl-5H-dibenzo[a,d]cyclohepten-10-yl)-piperazine::CHEMBL432762

SMILES CC1c2ccccc2C=C(N2CCN(C)CC2)c2ccccc12

InChI Key InChIKey=NLYUVFZOJUSMNV-UHFFFAOYSA-N

Data  9 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50036438   

TargetD(4) dopamine receptor(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50036438(1-Methyl-4-(5-methyl-5H-dibenzo[a,d]cyclohepten-10...)
Affinity DataKi:  12nMAssay Description:Affinity was evaluated by inhibition of [3H]-spiperone binding to COS cells transfected with human dopamine D-4 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50036438(1-Methyl-4-(5-methyl-5H-dibenzo[a,d]cyclohepten-10...)
Affinity DataKi:  12nMAssay Description:Ability to inhibit the binding of [3H]spiperone to the Dopamine receptor D4 in COS7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetD(1A) dopamine receptor(Rat)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50036438(1-Methyl-4-(5-methyl-5H-dibenzo[a,d]cyclohepten-10...)
Affinity DataKi:  16nMAssay Description:Affinity was evaluated as inhibition constant for dopamine receptor D1 using [3H]-SCH- 23390 as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Rat)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50036438(1-Methyl-4-(5-methyl-5H-dibenzo[a,d]cyclohepten-10...)
Affinity DataKi:  36nMAssay Description:Affinity was evaluated by inhibition of [125I]LSD binding to NIH 3T3 cells transfected with cloned rat 5-hydroxytryptamine 2C receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Rat)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50036438(1-Methyl-4-(5-methyl-5H-dibenzo[a,d]cyclohepten-10...)
Affinity DataKi:  36nMAssay Description:Ability to inhibit the binding of iodine-125-labelled lysergic acid diethylamide([125I]-LSD) to the S-2C serotonin receptor in NIH3T3 cell line membr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50036438(1-Methyl-4-(5-methyl-5H-dibenzo[a,d]cyclohepten-10...)
Affinity DataKi:  47nMAssay Description:Affinity was evaluated by inhibition of [125I]LSD binding to NIH 3T3 cells transfected with cloned rat 5-hydroxytryptamine 2A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50036438(1-Methyl-4-(5-methyl-5H-dibenzo[a,d]cyclohepten-10...)
Affinity DataKi:  47nMAssay Description:Ability to inhibit the binding of iodine-125-labelled lysergic acid diethylamide([125I]-LSD) to the S-2A serotonin receptor in NIH3T3 cell line membr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50036438(1-Methyl-4-(5-methyl-5H-dibenzo[a,d]cyclohepten-10...)
Affinity DataKi:  94nMAssay Description:Affinity was evaluated by inhibition of [3H]spiperone binding to COS cells transfected with human dopamine D-2(long) receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM50036438(1-Methyl-4-(5-methyl-5H-dibenzo[a,d]cyclohepten-10...)
Affinity DataKi:  94nMAssay Description:Ability to inhibit the binding of [3H]spiperone to the D2L dopamine receptor in COS7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed