BDBM50036060 1-Oxo-2-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-2,9-dihydro-1H-beta-carboline-8-carboxylic acid::CHEMBL174215

SMILES CC(C)C(NC(=O)Cn1ccc2c(nc3c(cccc23)C(O)=O)c1O)C(=O)C(F)(F)F

InChI Key InChIKey=PICXFJCJWZQPEA-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50036060   

TargetNeutrophil elastase(Human)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036060(1-Oxo-2-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propyl...)
Affinity DataKi:  22nMAssay Description:In vitro inhibitory activity against human leukocyte elastase (HLE) mediated hydrolysis of the synthetic substrate MeO-Suc-Ala-Ala-Pro-Val-pNAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAngiotensin-converting enzyme(Rabbit)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036060(1-Oxo-2-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propyl...)
Affinity DataKi:  9.40E+4nMAssay Description:Inhibitory activity against rabbit Angiotensin I converting enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin G(Human)
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50036060(1-Oxo-2-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propyl...)
Affinity DataKi:  1.30E+5nMAssay Description:Inhibitory activity against human cathepsin G.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed