BDBM50035881 CHEMBL3361029::US9302985, 8

SMILES CC(C)CN(Cc1ccccc1)S(=O)(=O)c1ccc(cc1)-c1ccc(cc1)S(C)(=O)=O

InChI Key InChIKey=FNAVMDBQISQDTL-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50035881   

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandPNGBDBM50035881(US9302985, 8 | CHEMBL3361029)
Affinity DataIC50: 158nMpH: 7.4 T: 2°CAssay Description:On day of the assay, 100 μL of 0.05% CHAPS (in deionized H2O) was added to all wells of the GFB Unifilter plate and allowed soak for 1 h. A wash b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/21/2017
Entry Details
Go to US Patent

TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandPNGBDBM50035881(US9302985, 8 | CHEMBL3361029)
Affinity DataIC50: 160nMAssay Description:Displacement of [3H]25-hydroxycholesterol from human RORc-LBD expressed in bacterial expression system after 3 hrs by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2016
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Genentech

US Patent
LigandPNGBDBM50035881(US9302985, 8 | CHEMBL3361029)
Affinity DataEC50: >2.00E+4nMAssay Description:Inverse agonist activity at N-terminal 6xHis-tagged human RORc ligand binding domain expressed in bacterial expression system assessed as inhibition ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/15/2016
Entry Details Article
PubMed