BDBM500349 7-[[5-(4- methylpiperazin- 1-yl)-2- pyridyl]amino]- 4-(1H- pyrrolo[2,3- b]pyridin-3- yl)-2,3- dihydropyrrolo [3,4-c]pyridin-1- one::US11021481, Compound I-6::US11078201, Compound I-6::US11548890, Compound I-6

SMILES CN1CCN(CC1)c1ccc(Nc2cnc(c3CNC(=O)c23)-c2c[nH]c3ncccc23)nc1

InChI Key InChIKey=SQOZULSCEZESNP-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 500349   

LigandPNGBDBM500349(US11021481, Compound I-6 | 7-[[5-(4- methylpiperaz...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
Go to US Patent

LigandPNGBDBM500349(US11021481, Compound I-6 | 7-[[5-(4- methylpiperaz...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
Go to US Patent

LigandPNGBDBM500349(US11021481, Compound I-6 | 7-[[5-(4- methylpiperaz...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
Go to US Patent

LigandPNGBDBM500349(US11021481, Compound I-6 | 7-[[5-(4- methylpiperaz...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
Go to US Patent

LigandPNGBDBM500349(US11021481, Compound I-6 | 7-[[5-(4- methylpiperaz...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details
Go to US Patent