BDBM50034843 (2R,4S)-5-Biphenyl-4-yl-4-(2-carboxy-acetylamino)-2-methyl-pentanoic acid::CHEMBL45972::US20230285340, Compound 21g

SMILES C[C@H](C[C@@H](Cc1ccc(cc1)-c1ccccc1)NC(=O)CC(O)=O)C(O)=O

InChI Key InChIKey=XBSAFVSKJABWDV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50034843   

TargetNeprilysin(Rat)
Ciba-Geigy

Curated by ChEMBL
LigandPNGBDBM50034843((2R,4S)-5-Biphenyl-4-yl-4-(2-carboxy-acetylamino)-...)
Affinity DataIC50: 92nMAssay Description:In vitro inhibition of rat neutral endopeptidase by using GAAP as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNeprilysin/Angiotensin-converting enzyme(Human)
Theravance Biopharma R&D Ip

US Patent
LigandPNGBDBM50034843((2R,4S)-5-Biphenyl-4-yl-4-(2-carboxy-acetylamino)-...)
Affinity DataIC50: 92nMAssay Description:NEP inhibitors, such as thiorphan, candoxatril, and candoxatrilat, have been studied as potential therapeutics. Compounds that inhibit both NEP and a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2023
Entry Details
Go to US Patent