BDBM50034473 Biphenyl-3-sulfonic acid (3,4-dimethyl-isoxazol-5-yl)-amide::CHEMBL417651

SMILES Cc1noc(NS(=O)(=O)c2cccc(c2)-c2ccccc2)c1C

InChI Key InChIKey=PFKPCLJGCDINDK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50034473   

TargetEndothelin-1 receptor(Rat)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50034473(Biphenyl-3-sulfonic acid (3,4-dimethyl-isoxazol-5-...)
Affinity DataIC50: 5.40E+3nMAssay Description:Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50034473(Biphenyl-3-sulfonic acid (3,4-dimethyl-isoxazol-5-...)
Affinity DataIC50: 4.90E+3nMAssay Description:Binding affinity against human Endothelin B receptor in transfected COS 7 cell membrane preparationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetEndothelin-1 receptor(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50034473(Biphenyl-3-sulfonic acid (3,4-dimethyl-isoxazol-5-...)
Affinity DataIC50: 580nMAssay Description:Binding affinity against human Endothelin A receptor in TE 671(ATCC# HTB 139) cell membrane preparationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article