BDBM50034465 CHEMBL30199::N-[5-(3,4-Dimethyl-isoxazol-5-ylsulfamoyl)-naphthalen-1-yl]-acetamide

SMILES CC(=O)Nc1cccc2c(cccc12)S(=O)(=O)Nc1onc(C)c1C

InChI Key InChIKey=RUCGYYIEJGBLLO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50034465   

TargetEndothelin-1 receptor(Rat)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50034465(N-[5-(3,4-Dimethyl-isoxazol-5-ylsulfamoyl)-naphtha...)
Affinity DataIC50: 880nMAssay Description:Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Rat)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50034465(N-[5-(3,4-Dimethyl-isoxazol-5-ylsulfamoyl)-naphtha...)
Affinity DataIC50: 87nMAssay Description:Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50034465(N-[5-(3,4-Dimethyl-isoxazol-5-ylsulfamoyl)-naphtha...)
Affinity DataIC50: 880nMAssay Description:Ability to inhibit [125I]ET1 binding to vascular smooth muscle (vsm)- A10 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed