BDBM50034433 4-Amino-N-(4,5-dimethyl-isoxazol-3-yl)-benzenesulfonamide::CHEMBL26630::Sulfatroxazole

SMILES Cc1onc(NS(=O)(=O)c2ccc(N)cc2)c1C

InChI Key InChIKey=DAUFGBIKKGOPJA-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50034433   

TargetEndothelin-1 receptor(Rat)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50034433(Sulfatroxazole | 4-Amino-N-(4,5-dimethyl-isoxazol-...)
Affinity DataIC50: 260nMAssay Description:Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Rat)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50034433(Sulfatroxazole | 4-Amino-N-(4,5-dimethyl-isoxazol-...)
Affinity DataIC50: 260nMAssay Description:Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Rat)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50034433(Sulfatroxazole | 4-Amino-N-(4,5-dimethyl-isoxazol-...)
Affinity DataIC50: 5.00E+3nMAssay Description:Displacement of [125 I] ET-1 from rat aortic smooth muscle A7r5 cells transfected with Endothelin A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed