BDBM50034418 5-Hydroxy-naphthalene-1-sulfonic acid (3,4-dimethyl-isoxazol-5-yl)-amide::CHEMBL30228

SMILES Cc1noc(NS(=O)(=O)c2cccc3c(O)cccc23)c1C

InChI Key InChIKey=YOPBFWQDJCIHDV-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50034418   

TargetEndothelin-1 receptor(Rat)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50034418(5-Hydroxy-naphthalene-1-sulfonic acid (3,4-dimethy...)
Affinity DataIC50: 7.80E+3nMAssay Description:Antagonism of [125 I]ET-1 binding to the rat endothelin receptor in vascular smooth muscle VSM-A10 cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Rat)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50034418(5-Hydroxy-naphthalene-1-sulfonic acid (3,4-dimethy...)
Affinity DataIC50: 68nMAssay Description:Inhibition of [125I]endothelin-l binding to endothelin A receptor of rat thoracic aorta smooth muscle cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50034418(5-Hydroxy-naphthalene-1-sulfonic acid (3,4-dimethy...)
Affinity DataIC50: 7.80E+3nMAssay Description:Antagonism of ET1 induced increase in intracellular Ca+2 in rabbit carotid artery ringsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed