BDBM50034271 4-(3,5-Bis-trifluoromethyl-benzyloxymethyl)-4-phenyl-piperidine::CHEMBL422931

SMILES FC(F)(F)c1cc(COCC2(CCNCC2)c2ccccc2)cc(c1)C(F)(F)F

InChI Key InChIKey=GZAMCYJCPQMIHJ-UHFFFAOYSA-N

Data  16 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50034271   

TargetSubstance-P receptor(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50034271(4-(3,5-Bis-trifluoromethyl-benzyloxymethyl)-4-phen...)
Affinity DataIC50: 0.950nMAssay Description:Antagonistic activity against human Tachykinin receptor 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50034271(4-(3,5-Bis-trifluoromethyl-benzyloxymethyl)-4-phen...)
Affinity DataIC50: 0.950nMAssay Description:Binding affinity at human tachykinin receptor 1 by measuring its ability to displace [125I]-labeled substance P from the cloned receptor expressed in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50034271(4-(3,5-Bis-trifluoromethyl-benzyloxymethyl)-4-phen...)
Affinity DataIC50: 0.950nMAssay Description:Displacement of [125I]-labeled substance P from the cloned Tachykinin receptor 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50034271(4-(3,5-Bis-trifluoromethyl-benzyloxymethyl)-4-phen...)
Affinity DataIC50: 1nMAssay Description:Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50034271(4-(3,5-Bis-trifluoromethyl-benzyloxymethyl)-4-phen...)
Affinity DataIC50: 1nMAssay Description:Displacement of [125I]RTI-55 from human recombinant SERT expressed in HEK293 cells after 1 hr by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50034271(4-(3,5-Bis-trifluoromethyl-benzyloxymethyl)-4-phen...)
Affinity DataIC50: 1nMAssay Description:Displacement of [125I]substance P from human recombinant NK1 receptor expressed in human U373 cells after 1 hr by scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50034271(4-(3,5-Bis-trifluoromethyl-benzyloxymethyl)-4-phen...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of NK3 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetSubstance-K receptor(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50034271(4-(3,5-Bis-trifluoromethyl-benzyloxymethyl)-4-phen...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of NK2 receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50034271(4-(3,5-Bis-trifluoromethyl-benzyloxymethyl)-4-phen...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of 5HT2C receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50034271(4-(3,5-Bis-trifluoromethyl-benzyloxymethyl)-4-phen...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of 5HT2B receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50034271(4-(3,5-Bis-trifluoromethyl-benzyloxymethyl)-4-phen...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of 5HT2A receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50034271(4-(3,5-Bis-trifluoromethyl-benzyloxymethyl)-4-phen...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of 5HT1B receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50034271(4-(3,5-Bis-trifluoromethyl-benzyloxymethyl)-4-phen...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of 5HT1A receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50034271(4-(3,5-Bis-trifluoromethyl-benzyloxymethyl)-4-phen...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of NET (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50034271(4-(3,5-Bis-trifluoromethyl-benzyloxymethyl)-4-phen...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of DAT (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
Merck Sharp and Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50034271(4-(3,5-Bis-trifluoromethyl-benzyloxymethyl)-4-phen...)
Affinity DataIC50: 0.955nMAssay Description:Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed