BDBM50034270 3-Benzo[1,3]dioxol-5-yl-4-benzyl-5-hydroxy-5-(4-methoxy-3-methyl-phenyl)-5H-furan-2-one::CHEMBL10588

SMILES COc1ccc(cc1C)C1(O)OC(=O)C(=C1Cc1ccccc1)c1ccc2OCOc2c1

InChI Key InChIKey=WWMOPKHFPOIUHU-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50034270   

TargetEndothelin-1 receptor(Human)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50034270(3-Benzo[1,3]dioxol-5-yl-4-benzyl-5-hydroxy-5-(4-me...)
Affinity DataIC50: 12nMAssay Description:Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50034270(3-Benzo[1,3]dioxol-5-yl-4-benzyl-5-hydroxy-5-(4-me...)
Affinity DataIC50: 1.75E+3nMAssay Description:Tested for antagonistic activity against Endothelin B receptor in the humans (CHO expressed).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Human)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50034270(3-Benzo[1,3]dioxol-5-yl-4-benzyl-5-hydroxy-5-(4-me...)
Affinity DataIC50: 12nMAssay Description:Antagonistic activity against human Endothelin A receptor expressed in LtKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Human)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50034270(3-Benzo[1,3]dioxol-5-yl-4-benzyl-5-hydroxy-5-(4-me...)
Affinity DataIC50: 12nMAssay Description:Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50034270(3-Benzo[1,3]dioxol-5-yl-4-benzyl-5-hydroxy-5-(4-me...)
Affinity DataIC50: 1.75E+3nMAssay Description:Binding affinity against human cloned Endothelin B receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed