BDBM50034258 3-Benzo[1,3]dioxol-5-yl-4-benzyl-5-hydroxy-5-p-tolyl-5H-furan-2-one::CHEMBL273613

SMILES Cc1ccc(cc1)C1(O)OC(=O)C(=C1Cc1ccccc1)c1ccc2OCOc2c1

InChI Key InChIKey=HUUWRVJBRKRKHX-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50034258   

TargetEndothelin-1 receptor(Human)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50034258(3-Benzo[1,3]dioxol-5-yl-4-benzyl-5-hydroxy-5-p-tol...)
Affinity DataIC50: 1.20E+3nMAssay Description:Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Human)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50034258(3-Benzo[1,3]dioxol-5-yl-4-benzyl-5-hydroxy-5-p-tol...)
Affinity DataIC50: 4.90E+3nMAssay Description:Antagonistic activity against human Endothelin A receptor expressed in LtKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Rat)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50034258(3-Benzo[1,3]dioxol-5-yl-4-benzyl-5-hydroxy-5-p-tol...)
Affinity DataIC50: 4.50E+3nMAssay Description:Tested for antagonistic activity against Endothelin B receptor in the rat cerebellum.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50034258(3-Benzo[1,3]dioxol-5-yl-4-benzyl-5-hydroxy-5-p-tol...)
Affinity DataIC50: 2.50E+4nMAssay Description:Tested for antagonistic activity against Endothelin B receptor in human (CHO expressed).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Human)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50034258(3-Benzo[1,3]dioxol-5-yl-4-benzyl-5-hydroxy-5-p-tol...)
Affinity DataIC50: 4.90E+3nMAssay Description:Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50034258(3-Benzo[1,3]dioxol-5-yl-4-benzyl-5-hydroxy-5-p-tol...)
Affinity DataIC50: 2.50E+4nMAssay Description:Binding affinity against human cloned Endothelin B receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed