BDBM50034254 3-(4-Chloro-phenyl)-5-hydroxy-4-(4-methoxy-benzyl)-5-(4-methoxy-phenyl)-5H-furan-2-one::CHEMBL10648

SMILES COc1ccc(CC2=C(C(=O)OC2(O)c2ccc(OC)cc2)c2ccc(Cl)cc2)cc1

InChI Key InChIKey=RQUIHRSTPLMWSU-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50034254   

TargetEndothelin-1 receptor(Human)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50034254(3-(4-Chloro-phenyl)-5-hydroxy-4-(4-methoxy-benzyl)...)
Affinity DataIC50: 960nMAssay Description:Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50034254(3-(4-Chloro-phenyl)-5-hydroxy-4-(4-methoxy-benzyl)...)
Affinity DataIC50: 2.50E+3nMAssay Description:Tested for antagonistic activity against Endothelin B receptor in the humans (CHO expressed).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Human)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50034254(3-(4-Chloro-phenyl)-5-hydroxy-4-(4-methoxy-benzyl)...)
Affinity DataIC50: 700nMAssay Description:Antagonistic activity against human Endothelin A receptor expressed in LtKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Human)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50034254(3-(4-Chloro-phenyl)-5-hydroxy-4-(4-methoxy-benzyl)...)
Affinity DataIC50: 700nMAssay Description:Binding affinity against human cloned endothelin A receptor expressed in LTK-cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50034254(3-(4-Chloro-phenyl)-5-hydroxy-4-(4-methoxy-benzyl)...)
Affinity DataIC50: 2.50E+3nMAssay Description:Binding affinity against human cloned Endothelin B receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed