BDBM50033817 3-(3,5-Bis-trifluoromethyl-benzyl)-5-(1H-indol-3-ylmethyl)-oxazolidine-2,4-dione::CHEMBL120844::CHEMBL367711

SMILES Oc1c(Cc2c[nH]c3ccccc23)oc(=O)n1Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F

InChI Key InChIKey=VIDKMLPYRVIQMN-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50033817   

TargetSubstance-P receptor(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50033817(CHEMBL367711 | CHEMBL120844 | 3-(3,5-Bis-trifluoro...)
Affinity DataIC50: 22nMAssay Description:Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50033817(CHEMBL367711 | CHEMBL120844 | 3-(3,5-Bis-trifluoro...)
Affinity DataIC50: 25nMAssay Description:Antagonist activity at NK1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2011
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50033817(CHEMBL367711 | CHEMBL120844 | 3-(3,5-Bis-trifluoro...)
Affinity DataIC50: 22nMAssay Description:Binding affinity at human Tachykinin receptor 1 expressed in CHO cells by [125 I]Trp8-substance P displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/31/2012
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50033817(CHEMBL367711 | CHEMBL120844 | 3-(3,5-Bis-trifluoro...)
Affinity DataIC50: 25.7nMAssay Description:Binding affinity was measured against the Tachykinin receptor 1 in CHO-expressed hNK1 using [125I]SP.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed