BDBM50033762 Gallinamide A
SMILES CC[C@H](C)[C@H](N(C)C)C(=O)O[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)\C=C\C(=O)N1[C@@H](C)C(OC)=CC1=O
InChI Key InChIKey=ASRBKZHDORPEHO-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 25 hits for monomerid = 50033762
Affinity DataIC50: 140nMAssay Description:Inhibition of human Cathepsin V using Z-Phe-Arg-aminomethylcoumarin as substrate preincubated for 30 mins followed by substrate additionMore data for this Ligand-Target Pair
TargetCysteine proteinase falcipain 3(Plasmodium falciparum (isolate 3D7))
University of Petroleum and Energy Studies
Curated by ChEMBL
University of Petroleum and Energy Studies
Curated by ChEMBL
Affinity DataIC50: 22nMAssay Description:Inhibition of Plasmodium falciparum D10 trophozite lysates FP-3 pretreated with compound for 1 hr followed by labeling with Cy5-DCG04 for 1 hr by flu...More data for this Ligand-Target Pair
TargetFalcipain 2(malaria parasite P. falciparum)
University of Petroleum and Energy Studies
Curated by ChEMBL
University of Petroleum and Energy Studies
Curated by ChEMBL
Affinity DataIC50: 8.5nMAssay Description:Inhibition of Plasmodium falciparum D10 trophozite lysates FP-2 pretreated with compound for 1 hr followed by labeling with Cy5-DCG04 for 1 hr by flu...More data for this Ligand-Target Pair
Affinity DataIC50: 79.6nMAssay Description:Inhibition of human recombinant Cathepsin K assessed remaining activity using Z-FR-AMC as substrate incubated for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Inhibition of Trypanosoma cruzi cruzain using Z-FR-AMC as substrate preincubated for 10 mins followed by substrate addition by fluorimetric analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 0.367nMAssay Description:Inhibition of human recombinant Cathepsin S assessed remaining activity using Z-FR-AMC as substrate incubated for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 697nMAssay Description:Inhibition of human recombinant Cathepsin V assessed remaining activity using Z-FR-AMC as substrate incubated for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 7.30nMAssay Description:Inhibition of human recombinant Cathepsin B assessed remaining activity using Z-FR-AMC as substrate incubated for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0180nMAssay Description:Inhibition of human recombinant Cathepsin L assessed remaining activity using Z-FR-AMC as substrate incubated for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 460nMAssay Description:Inhibition of human Cathepsin V using Z-Phe-Arg-aminomethylcoumarin as substrateMore data for this Ligand-Target Pair
TargetFalcipain 2(malaria parasite P. falciparum)
University of Petroleum and Energy Studies
Curated by ChEMBL
University of Petroleum and Energy Studies
Curated by ChEMBL
Affinity DataIC50: 8.5nMAssay Description:Inhibition of FP2' in Plasmodium falciparum trophozoite stage after 1 hr by SDS-PAGE analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 47nMAssay Description:Inhibition of recombinant human Cathepsin L using Z-Phe-Arg-aminomethylcoumarin as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of human Cathepsin B using Z-Phe-Arg-aminomethylcoumarin as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of human Cathepsin B using Z-Phe-Arg-aminomethylcoumarin as substrate preincubated for 30 mins followed by substrate additionMore data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human Cathepsin H using Arg-aminomethylcoumarin as substrate preincubated for 30 mins followed by substrate additionMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant human Cathepsin L using Z-Phe-Arg-aminomethylcoumarin as substrate preincubated for 30 mins followed by substrate additionMore data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human Cathepsin H using Arg-aminomethylcoumarin as substrateMore data for this Ligand-Target Pair
Affinity DataKoff: 9.00E+3s-1Assay Description:Irreversible inhibition of recombinant human cathepsin L using Z-Phe-Arg-aminomethylcoumarin as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 0.260nMAssay Description:Inhibition of recombinant Trypanosoma cruzi Cruzain expressed in Pichia pastoris using Z-Phe-Arg-AMC substrate incubated for 30 mins by fluorescence ...More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of human cathepsin LMore data for this Ligand-Target Pair
Affinity DataIC50: 4.70nMAssay Description:Inhibition of human cathepsin L using fluorogenic substrate cbz-FR-AMC monitored for 90 to 120 mins by spectrophotometryMore data for this Ligand-Target Pair
TargetFalcipain 2(malaria parasite P. falciparum)
University of Petroleum and Energy Studies
Curated by ChEMBL
University of Petroleum and Energy Studies
Curated by ChEMBL
Affinity DataIC50: 8.5nMAssay Description:Inhibition of FP2 in Plasmodium falciparum trophozoite stage after 1 hr by SDS-PAGE analysisMore data for this Ligand-Target Pair
Affinity DataKi: 5.30nMAssay Description:Inhibition of mouse Cathepsin L assessed as Apparent inhibition constant using Z-FR-AMC as substrate inubated for 30 mins by fluorometric assayMore data for this Ligand-Target Pair
Affinity DataKi: 8nMAssay Description:Inhibition of human recombinant Cathepsin L assessed as Apparent inhibition constant using Z-FR-AMC as substrate inubated for 30 mins by fluorometric...More data for this Ligand-Target Pair
Affinity DataKi: 117nMAssay Description:Inhibition of human recombinant Cathepsin B assessed as Apparent inhibition constant using Z-FR-AMC as substrate inubated for 30 mins by fluorometric...More data for this Ligand-Target Pair