BDBM50033555 6-{[Prop-2-ynyl-(3,4,5-trimethoxy-phenyl)-amino]-methyl}-5,6,7,8-tetrahydro-quinazoline-2,4-diamine::CHEMBL120821

SMILES COc1cc(cc(OC)c1OC)N(CC#C)CC1CCc2nc(N)nc(N)c2C1

InChI Key InChIKey=GSNSXRQZCOZUTN-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50033555   

TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50033555(6-{[Prop-2-ynyl-(3,4,5-trimethoxy-phenyl)-amino]-m...)
Affinity DataIC50: 12nMAssay Description:Inhibitory activity against purified Dihydrofolate reductase from Toxoplasma gondii.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50033555(6-{[Prop-2-ynyl-(3,4,5-trimethoxy-phenyl)-amino]-m...)
Affinity DataIC50: 119nMAssay Description:Inhibitory activity against purified dihydrofolate reductase from Pneumocystis carinii.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50033555(6-{[Prop-2-ynyl-(3,4,5-trimethoxy-phenyl)-amino]-m...)
Affinity DataIC50: 74nMAssay Description:Inhibitory activity against purified dihydrofolate reductase from ratMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50033555(6-{[Prop-2-ynyl-(3,4,5-trimethoxy-phenyl)-amino]-m...)
Affinity DataIC50: 119nMAssay Description:Inhibition of Pneumocystis carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50033555(6-{[Prop-2-ynyl-(3,4,5-trimethoxy-phenyl)-amino]-m...)
Affinity DataIC50: 74nMAssay Description:Inhibition of rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50033555(6-{[Prop-2-ynyl-(3,4,5-trimethoxy-phenyl)-amino]-m...)
Affinity DataIC50: 12nMAssay Description:Inhibition of Toxoplasma gondii dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed