BDBM50033552 6-(2,3-Dihydro-indol-1-ylmethyl)-5,6,7,8-tetrahydro-quinazoline-2,4-diamine::CHEMBL120826

SMILES Nc1nc(N)c2CC(CN3CCc4ccccc34)CCc2n1

InChI Key InChIKey=QRPGXVPQNGORLI-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50033552   

TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50033552(6-(2,3-Dihydro-indol-1-ylmethyl)-5,6,7,8-tetrahydr...)
Affinity DataIC50: 27nMAssay Description:Inhibitory activity against purified DHFR (Dihydrofolate reductase) from Toxoplasma gondii.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50033552(6-(2,3-Dihydro-indol-1-ylmethyl)-5,6,7,8-tetrahydr...)
Affinity DataIC50: 160nMAssay Description:Inhibitory activity against purified DHFR (Dihydrofolate reductase) from ratMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50033552(6-(2,3-Dihydro-indol-1-ylmethyl)-5,6,7,8-tetrahydr...)
Affinity DataIC50: 210nMAssay Description:Inhibitory activity against purified DHFR (Dihydrofolate reductase) from Pneumocystis carinii.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50033552(6-(2,3-Dihydro-indol-1-ylmethyl)-5,6,7,8-tetrahydr...)
Affinity DataIC50: 27nMAssay Description:Inhibition of Toxoplasma gondii dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50033552(6-(2,3-Dihydro-indol-1-ylmethyl)-5,6,7,8-tetrahydr...)
Affinity DataIC50: 210nMAssay Description:Inhibition of Pneumocystis carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50033552(6-(2,3-Dihydro-indol-1-ylmethyl)-5,6,7,8-tetrahydr...)
Affinity DataIC50: 160nMAssay Description:Inhibition of rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed