BDBM50033549 6-[(2,5-Dimethoxy-phenylamino)-methyl]-5,6,7,8-tetrahydro-quinazoline-2,4-diamine::CHEMBL7263

SMILES COc1ccc(OC)c(NCC2CCc3nc(N)nc(N)c3C2)c1

InChI Key InChIKey=FKNBNLOFINZYOK-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50033549   

TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50033549(6-[(2,5-Dimethoxy-phenylamino)-methyl]-5,6,7,8-tet...)
Affinity DataIC50: 181nMAssay Description:Inhibitory activity against purified Dihydrofolate reductase from Toxoplasma gondii.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50033549(6-[(2,5-Dimethoxy-phenylamino)-methyl]-5,6,7,8-tet...)
Affinity DataIC50: 1.67E+3nMAssay Description:Inhibitory activity against purified dihydrofolate reductase from Pneumocystis carinii.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50033549(6-[(2,5-Dimethoxy-phenylamino)-methyl]-5,6,7,8-tet...)
Affinity DataIC50: 560nMAssay Description:Inhibitory activity against purified dihydrofolate reductase from ratMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50033549(6-[(2,5-Dimethoxy-phenylamino)-methyl]-5,6,7,8-tet...)
Affinity DataIC50: 1.70E+3nMAssay Description:The ability to inhibit Pneumocystis carinii Dihydrofolate reductase was testedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50033549(6-[(2,5-Dimethoxy-phenylamino)-methyl]-5,6,7,8-tet...)
Affinity DataIC50: 180nMAssay Description:The ability to inhibit Toxoplasma gondii Dihydrofolate reductase was testedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50033549(6-[(2,5-Dimethoxy-phenylamino)-methyl]-5,6,7,8-tet...)
Affinity DataIC50: 560nMAssay Description:The ability to inhibit rat liver Dihydrofolate reductase was testedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50033549(6-[(2,5-Dimethoxy-phenylamino)-methyl]-5,6,7,8-tet...)
Affinity DataIC50: 181nMAssay Description:Inhibition of Toxoplasma gondii dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50033549(6-[(2,5-Dimethoxy-phenylamino)-methyl]-5,6,7,8-tet...)
Affinity DataIC50: 1.67E+3nMAssay Description:Inhibition of Pneumocystis carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50033549(6-[(2,5-Dimethoxy-phenylamino)-methyl]-5,6,7,8-tet...)
Affinity DataIC50: 560nMAssay Description:Inhibition of rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed