BDBM50033545 6-[(4-Chloro-phenylamino)-methyl]-5,6,7,8-tetrahydro-quinazoline-2,4-diamine::CHEMBL121947

SMILES Nc1nc(N)c2CC(CNc3ccc(Cl)cc3)CCc2n1

InChI Key InChIKey=MCNPVOLBYMVRLQ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50033545   

TargetDihydrofolate reductase(Rat)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50033545(6-[(4-Chloro-phenylamino)-methyl]-5,6,7,8-tetrahyd...)
Affinity DataIC50: 128nMAssay Description:Inhibitory activity against purified DHFR (Dihydrofolate reductase) from ratMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50033545(6-[(4-Chloro-phenylamino)-methyl]-5,6,7,8-tetrahyd...)
Affinity DataIC50: 940nMAssay Description:Inhibitory activity against purified DHFR (Dihydrofolate reductase) from Pneumocystis carinii.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50033545(6-[(4-Chloro-phenylamino)-methyl]-5,6,7,8-tetrahyd...)
Affinity DataIC50: 78nMAssay Description:Inhibitory activity against purified DHFR (Dihydrofolate reductase) from Toxoplasma gondii.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed