BDBM50032954 5-(piperidin-4-yl)isoxazol-3-ol::5-Piperidin-4-yl-isoxazol-3-ol::5-Piperidin-4-yl-isoxazol-3-ol(4-PIOL)::CHEMBL311761

SMILES O=c1cc(o[nH]1)C1CCNCC1

InChI Key InChIKey=YYOYGSTYWVHCJR-UHFFFAOYSA-N

Data  1 KI  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50032954   

TargetPlasminogen(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50032954(5-Piperidin-4-yl-isoxazol-3-ol(4-PIOL) | 5-(piperi...)
Affinity DataIC50: 2.80E+3nMAssay Description:Binding affinity to human full length Glu-plasminogen in buffer assessed as inhibition of interaction with fibrin preincubated for 15 mins followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetPlasminogen(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50032954(5-Piperidin-4-yl-isoxazol-3-ol(4-PIOL) | 5-(piperi...)
Affinity DataIC50: 800nMAssay Description:Binding affinity to full length Glu-plasminogen in human plasma assessed as inhibition of interaction with fibrin in presence of tPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/11/2015
Entry Details Article
PubMed
TargetGamma-aminobutyric acid type B receptor subunit 1/2(Rat)
Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50032954(5-Piperidin-4-yl-isoxazol-3-ol(4-PIOL) | 5-(piperi...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of Gamma-aminobutyric acid type B receptor of rat cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetGamma-aminobutyric acid (GABA) B receptor 1(Rat)
The Royal Danish School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50032954(5-Piperidin-4-yl-isoxazol-3-ol(4-PIOL) | 5-(piperi...)
Affinity DataIC50: 1.00E+5nMAssay Description:Affinity for GABA-B receptor by inhibiting GABA uptake into rat brain synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2012
Entry Details Article
PubMed
TargetPlasminogen(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50032954(5-Piperidin-4-yl-isoxazol-3-ol(4-PIOL) | 5-(piperi...)
Affinity DataIC50: 800nMAssay Description:Inhibition of plasminogen/fibrinogen interaction in pooled citreated human platelet-poor plasma assessed as inhibition of lysis of CaCl2/t-PA-induced...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetPlasminogen(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50032954(5-Piperidin-4-yl-isoxazol-3-ol(4-PIOL) | 5-(piperi...)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of human Glu-plasminogen/fibrinogen interaction in HEPES buffer assessed as inhibition of lysis of thrombin-induced clot preincubated for ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50032954(5-Piperidin-4-yl-isoxazol-3-ol(4-PIOL) | 5-(piperi...)
Affinity DataIC50: 5.00E+5nMAssay Description:Agonist activity at human GABAA alpha-1-beta-2-gamma-2 receptor expressed in mouse tsA201 cells at < 500 uM by FMP red assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50032954(5-Piperidin-4-yl-isoxazol-3-ol(4-PIOL) | 5-(piperi...)
Affinity DataKi:  1.10E+4nMAssay Description:Antagonist activity at human GABAA alpha-1-beta-3-gamma-2S expressed in Xenopus oocytes by two-electrode voltage-clamp electrophysiologyMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed