BDBM50032907 CHEMBL3342790

SMILES FC(F)(F)c1ccc(cc1)S(=O)(=O)Nc1ccnn1-c1ccccn1

InChI Key InChIKey=BELMOVXJXHEYJT-UHFFFAOYSA-N

Data  2 KI  4 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50032907   

TargetOxytocin receptor(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50032907(CHEMBL3342790)
Affinity DataEC50:  8nMAssay Description:Agonist activity at human oxytocin receptor expressed CHO cells assessed as calcium flux by FLIPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2016
Entry Details Article
PubMed
TargetOxytocin receptor(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50032907(CHEMBL3342790)
Affinity DataEC50:  0.100nMAssay Description:Antagonist activity at human OTR expressed in HEK293 cell membranes assessed as inhibition of OT-induced increase in Ca2+ flux preincubated for 5 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2020
Entry Details Article
PubMed
TargetVasopressin V1a receptor(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50032907(CHEMBL3342790)
Affinity DataEC50:  0.158nMAssay Description:Antagonist activity at human vasopressin 1a receptor expressed in HEK293 cell membranes assessed as inhibition of AVP-induced increase in Ca2+ flux p...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2020
Entry Details Article
PubMed
TargetOxytocin receptor(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50032907(CHEMBL3342790)
Affinity DataEC50:  8nMAssay Description:Agonist activity at human OTR expressed in HEK293 cell membranes induction of IP1 accumulation at 0.1 to 10 uM measured after 1 hr by fluorescence as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2020
Entry Details Article
PubMed
TargetVasopressin V1a receptor(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50032907(CHEMBL3342790)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human vasopressin 1a receptor expressed in HEK293 cell membranes assessed as inhibition of AVP-induced IP1 accumulation measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2020
Entry Details Article
PubMed
TargetOxytocin receptor(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50032907(CHEMBL3342790)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human OTR expressed in CHO cell membranes assessed as inhibition of OT-induced IP1 accumulation measured after 1 hr by fluores...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2020
Entry Details Article
PubMed
TargetOxytocin receptor(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50032907(CHEMBL3342790)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human OTR expressed in HEK293 cell membranes assessed as inhibition of OT-induced IP1 accumulation measured after 1 hr by fluo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2020
Entry Details Article
PubMed
TargetVasopressin V1a receptor(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50032907(CHEMBL3342790)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human vasopressin 1a receptor expressed in CHO cell membranes assessed as inhibition of AVP-induced IP1 accumulation by measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2020
Entry Details Article
PubMed
TargetOxytocin receptor(Human)
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50032907(CHEMBL3342790)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]-oxytocin from human OTR expressed in HEK293 cell membranes after 90 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2020
Entry Details Article
PubMed
TargetVasopressin V1a receptor(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50032907(CHEMBL3342790)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]-vasopressin from human vasopressin 1a receptor expressed in HEK293 cell membranes after 90 mins by microbeta scintillation count...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2020
Entry Details Article
PubMed