BDBM50032537 (2S,3S)-8-Methyl-3-phenyl-2-propyl-8-aza-bicyclo[3.2.1]octane::CHEMBL420291

SMILES CCC[C@@H]1C2CCC(C[C@@H]1c1ccccc1)N2C

InChI Key

Data  5 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50032537   

TargetSodium-dependent dopamine transporter(Rat)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50032537((2S,3S)-8-Methyl-3-phenyl-2-propyl-8-aza-bicyclo[3...)
Affinity DataIC50: 23nMAssay Description:Inhibitory activity on dopamine transporters of rat striated membranes using [3H]- mazindol.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50032537((2S,3S)-8-Methyl-3-phenyl-2-propyl-8-aza-bicyclo[3...)
Affinity DataIC50: 95nMAssay Description:Inhibitory activity against Serotonin transporter was determined for [3H]5-HT (serotonin) uptake by striated synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50032537((2S,3S)-8-Methyl-3-phenyl-2-propyl-8-aza-bicyclo[3...)
Affinity DataIC50: 7.5nMAssay Description:Inhibitory activity determined for [3H]DA (Dopamine transporter) uptake by striated synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50032537((2S,3S)-8-Methyl-3-phenyl-2-propyl-8-aza-bicyclo[3...)
Affinity DataKi:  1.60nMAssay Description:Inhibition of [3H]dopamine binding to rat striatal synaptosome dopamine transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50032537((2S,3S)-8-Methyl-3-phenyl-2-propyl-8-aza-bicyclo[3...)
Affinity DataKi:  1.90nMAssay Description:Binding affinity towards dopamine transporter using [3H]-mazindol as radioligand in rat striatal membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50032537((2S,3S)-8-Methyl-3-phenyl-2-propyl-8-aza-bicyclo[3...)
Affinity DataKi:  6.90nMAssay Description:Binding affinity for [3H]DA (Dopamine transporter) uptake by striated synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50032537((2S,3S)-8-Methyl-3-phenyl-2-propyl-8-aza-bicyclo[3...)
Affinity DataKi:  12nMAssay Description:Binding affinity of compound on dopamine transporters of rat striated membranes using [3H]- mazindol.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50032537((2S,3S)-8-Methyl-3-phenyl-2-propyl-8-aza-bicyclo[3...)
Affinity DataKi:  87nMAssay Description:Binding affinity for Serotonin transporter was determined by [3H]5-HT (serotonin) uptake by striated synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/9/2012
Entry Details Article
PubMed